Silver-Russell syndrome (SRS)

Overview

SRS or Russell-Silver syndrome (RSS) as it is sometimes called, is a rare genetic growth disorder. Children are generally born smaller than expected with distinct facial features. Sometimes different parts of the body will grow at different rates. Children with SRS will not catch-up to normal height in the first 2 years of life, and will need treatment early on.

Cause

SRS is a genetic growth disorder caused by errors in different parts of some genes. It was originally documented in the 1950s by ‘Silver’ and ‘Russell’, who reported a number of children with low birth weights and short stature.

Symptoms

As many parts of the gene can be affected, there may be a number of symptoms. These can include low birth weight and short stature, distinct facial features, and sometimes a curvature in the child’s little finger (5th finger).

Diagnosis

Diagnosis of SRS can be difficult due to the varied features and symptoms. The healthcare professional will look at the physical symptoms as well as performing follow-up measurements of growth. Some of the distinct facial features may become less obvious with age, so it is vital to diagnose early so that an accurate diagnosis can be completed. Genetic testing may also help with the diagnosis.

Little girl typing numbers on calculator

Calculate your child’s growth

It is important to keep track of your child’s growth in order to identify if there is a problem early on. We recommend measuring your child every 6 months, which is now easier, with our simple to use growth calculator.

Male and female patients waiting in corridor of medical centre

Get prepared for talking to your doctor

If you are concerned about your child’s growth, don’t hesitate to speak with an HCP. They will be able to complete some measurements and investigate further if needed, potentially referring you on to a specialist. Here we can help you plan for both conversations.

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